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Article

R132 mutations in canine isocitrate dehydrogenase 1 (IDH1) lead to functional changes.

Veterinary research communications - 1 Mar 2018

Kawakami Shota, Ochiai Kazuhiko, Azakami Daigo, Kato Yuiko, Michishita Masaki, Morimatsu Masami, Ishiguro-Oonuma Toshina, Onozawa Eri, Watanabe Masami, Omi Toshinori

Abstract excerpt

Glioma is the second most common intracranial neoplasia in dogs, but the pathogenic mechanisms remain unclear. In humans, isocitrate dehydrogenase 1 (IDH1) is frequently mutated in gliomas. Although almost all human IDH1 mutations have been identified as involving the Arg132 codon, few studies have reported structural, functional, and mutational information for canine IDH1. Therefore, in this study, we cloned the...

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PMID: 29285579
DOI: 10.1007/s11259-017-9707-8

Genes

IDH1

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