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Article

Prognostic value of IDH1 mutations identified with PCR-RFLP assay in glioblastoma patients.

Molecular diagnosis & therapy - 1 Jun 2010

Bujko Mateusz, Kober Paulina, Matyja Ewa, Nauman Paweł, Dyttus-Cebulok Katarzyna, Czeremszyńska Beata, Bonicki Wiesław, Siedlecki Janusz A

Abstract excerpt

BACKGROUND AND OBJECTIVE: It has been shown that somatic missense mutations in codon 132 of the NADP+ dependent isocitrate dehydrogenase 1 (IDH1) gene occur frequently in primary brain tumors including highly malignant glioblastoma (GBM). The aim of this study was to evaluate a PCR-restriction fragment length polymorphism (RFLP)-based method for missense mutation detection and to estimate the prognostic value of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20560678
DOI: 10.1007/BF03256369

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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