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Article

Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation.

Neuro-oncology - 1 Jan 2013

Li Sichen, Chou Arthur P, Chen Weidong, Chen Ruihuan, Deng Yuzhong, Phillips Heidi S, Selfridge Julia, Zurayk Mira, Lou Jerry J, Everson Richard G, Wu Kuan-Chung, Faull Kym F, Cloughesy Timothy, Liau Linda M, Lai Albert

Abstract excerpt

Mutations in isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) are found in a subset of gliomas. Among the many phenotypic differences between mutant and wild-type IDH1/2 gliomas, the most salient is that IDH1/2 mutant glioma patients demonstrate markedly improved survival compared with IDH1/2 wild-type glioma patients. To address the mechanism underlying the superior clinical outcome of IDH1/2 mutant glioma...

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Source

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Identifiers

PMID: 23115158
DOI: 10.1093/neuonc/nos261
PMCID: PMC3534418

Genes

IDH1
IDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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