Article
Expanding the spectrum of IDH1 mutations in gliomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2013
Gupta Ruta, Flanagan Simon, Li Cheryl C Y, Lee Maggie, Shivalingham Brindha, Maleki Sanaz, Wheeler Helen R, Buckland Michael E
Abstract excerpt
Mutations in isocitrate dehydrogenase -1 or -2 (IDH1 or IDH2) are found in the majority of WHO grade II and III diffuse gliomas and secondary glioblastomas. IDH mutation screening is rapidly becoming part of the routine pathological work up of human brain tumors, providing both diagnostic and prognostic information. Here, we characterize four rare and novel IDH1 mutations identified in surgical human glioma...
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