Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IDH1/2 gene hotspot mutations in central nervous system tumours: analysis of 922 Chinese patients.

Pathology - 1 Dec 2016

Chen Ni, Yu Tianpin, Gong Jing, Nie Ling, Chen Xueqin, Zhang Mengni, Xu Miao, Tan Junya, Su Zhengzheng, Zhong Jinjing, Zhou Qiao

Abstract excerpt

Mutations of isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) genes have been identified as early molecular events in the development of astrocytomas and oligodendrogliomas. Data regarding the status and prevalence of IDH1/2 mutations in Chinese patients are limited. Herein we report our data from West China Hospital, a major Chinese medical centre. IDH1(R132H) mutation was analysed by immunohistochemistry with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytoma
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease-Free Survival

Share to Glioblastoma

Share to Isocitrate Dehydrogenase

Share to Kaplan-Meier Estimate

Share to Proportional Hazards Models

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 27780605
DOI: 10.1016/j.pathol.2016.07.010

Genes

IDH1
IDH2
EGFR
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IDH1/2 gene hotspot mutations in central nervous system tumours: analysis of 922 Chinese patients.PMID 27780605Read ↗

Isocitrate Dehydrogenase IDH1 and IDH2 Mutations in Human Cancer: Prognostic Implications for Gliomas.Semantic proximity Read ↗

Non-canonical IDH1 and IDH2 mutations: a clonal and relevant event in an Italian cohort of gliomas classified according to the 2016 World Health Organization (WHO) criteria.Semantic proximity Read ↗

Expanding the spectrum of IDH1 mutations in gliomas.Semantic proximity Read ↗

Determining IDH-Mutational Status in Gliomas Using IDH1-R132H Antibody and Polymerase Chain ReactionSemantic proximity Read ↗

Analysis of IDH1 and IDH2 mutations in Japanese glioma patients.Semantic proximity Read ↗

Molecular investigation of isocitrate dehydrogenase gene (IDH) mutations in gliomas: first report of IDH2 mutations in Indian patients.Semantic proximity Read ↗

Immunohistochemical analysis of 1844 human epithelial and haematopoietic tumours and sarcomas for IDH1R132H mutation.Semantic proximity Read ↗

Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China.Semantic proximity Read ↗

Clinical and Molecular Features of Patients with Gliomas Harboring Idh1 Non-Canonical Mutations: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Clinical and Molecular Features of Patients with Gliomas Harboring IDH1 Non-canonical Mutations: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

A new sensitive PCR assay for one-step detection of 12 IDH1/2 mutations in glioma.Semantic proximity Read ↗

IDH1/2 Mutations in Patients With Diffuse Gliomas: A Single Centre Retrospective Massively Parallel Sequencing Analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.