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Article

Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1.

BMC medical genetics - 4 May 2014

Gee Fiona, Clubbs Clare F, Raine Emma V A, Reynard Louise N, Loughlin John

Abstract excerpt

BACKGROUND: An osteoarthritis (OA) susceptibility locus has been mapped to chromosome 3p21, to a region of high linkage disequilibrium encompassing twelve genes. Six of these genes are expressed in joint tissues and we therefore assessed whether any of the six were subject to cis-acting regulatory polymorphisms active in these tissues and which could therefore account for the association signal. METHODS: We...

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Identifiers

PMID: 24886551
DOI: 10.1186/1471-2350-15-53
PMCID: PMC4101866

Genes

GNL3
SPCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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