Article
Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3.
BMC medical genetics - 2 Mar 2012
Ratnayake Madhushika, Reynard Louise N, Raine Emma V A, Santibanez-Koref Mauro, Loughlin John
Abstract excerpt
BACKGROUND: A genome-wide association scan with subsequent replication study that involved over 67,000 individuals of European ancestry has produced evidence of association of single nucleotide polymorphism rs2277831 to primary osteoarthritis (OA) with a P-value of 2.9 × 10(-5). rs2277831, an A/G transition, is located in an intron of MICAL3. This gene is located on chromosome 22q11.21 and the association signal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.