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Article

Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22.

Annals of the rheumatic diseases - 1 Dec 2012

Raine E V A, Wreglesworth N, Dodd A W, Reynard L N, Loughlin J

Abstract excerpt

OBJECTIVES: An osteoarthritis (OA) susceptibility locus has been mapped to chromosome 7q22, to a region of high-linkage disequilibrium encompassing six genes: PRKAR2B, HBP1, COG5, GPR22, DUS4L and BCAP29. The authors assessed whether these genes were subject to cis-acting regulatory polymorphisms that are active in joint tissues and which could contribute to the association signal. METHODS: Using joint tissues...

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Share to Adaptor Proteins, Vesicular Transport
Share to Chromosomes, Human, Pair 7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hip Joint

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Share to Osteoarthritis, Knee

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Share to Receptors, G-Protein-Coupled

Source

Identifiers

PMID: 22586168
DOI: 10.1136/annrheumdis-2012-201304

Genes

HBP1
GPR22
BCAP29
COG5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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