Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism.

doi:10.1002/art.24616

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Article

Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism.

Arthritis and rheumatism - 1 Jul 2009

Egli Rainer J, Southam Lorraine, Wilkins James M, Lorenzen Inken, Pombo-Suarez Manuel, Gonzalez Antonio, Carr Andrew, Chapman Kay, Loughlin John

Abstract excerpt

OBJECTIVE: Single-nucleotide polymorphism (SNP) rs143383 (T to C) in the 5'-untranslated region (5'-UTR) of GDF5 has recently been reported to be associated with osteoarthritis (OA) susceptibility, with lower expression of the risk-associated T allele observed in vitro and in vivo. The in vivo studies were performed on cartilage tissue from OA patients. The present study was undertaken to expand the analysis of...

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PMID: 19565498
DOI: 10.1002/art.24616
PMCID: PMC6860363

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GDF5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism.PMID 19565498Read ↗

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