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Article

Cis- and trans-acting gene regulation is associated with osteoarthritis.

American journal of human genetics - 1 May 2006

Mahr Sandra, Burmester Gerd-Rüdiger, Hilke Dietmar, Göbel Udo, Grützkau Andreas, Häupl Thomas, Hauschild Matthias, Koczan Dirk, Krenn Veit, Neidel Jasper, Perka Carsten, Radbruch Andreas, Thiesen Hans-Jürgen, Müller Brigitte

Abstract excerpt

Osteoarthritis (OA) is a complex disease of the skeleton and is associated with aging. Both environmental and genetic factors contribute to its pathogenesis. We set out to identify novel genes associated with OA, concentrating on regulatory polymorphisms allowing for differential expression. Our strategy to identify differentially expressed genes included an initial transcriptome analysis of the peripheral blood...

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PMID: 16642435
DOI: 10.1086/503849
PMCID: PMC1474041

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RHOB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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