Article
Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis.
Rheumatology (Oxford, England) - 3 Apr 2023
Coutinho de Almeida Rodrigo, Tuerlings Margo, Ramos Yolande, Den Hollander Wouter, Suchiman Eka, Lakenberg Nico, Nelissen Rob G H H, Mei Hailiang, Meulenbelt Ingrid
Abstract excerpt
OBJECTIVES: To present an unbiased approach to identify positional transcript single nucleotide polymorphisms (SNPs) of osteoarthritis (OA) risk loci by allelic expression imbalance (AEI) analyses using RNA sequencing of articular cartilage and subchondral bone from OA patients. METHODS: RNA sequencing from 65 articular cartilage and 24 subchondral bone from OA patients was used for AEI analysis. AEI was...
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