Article
Multi-Tissue Epigenetic and Gene Expression Analysis Combined With Epigenome Modulation Identifies RWDD2B as a Target of Osteoarthritis Susceptibility.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Jan 2021
Parker Eleanor, Hofer Ines M J, Rice Sarah J, Earl Lucy, Anjum Sami A, Deehan David J, Loughlin John
Abstract excerpt
OBJECTIVE: Osteoarthritis (OA) is polygenic, with more than 90 risk loci currently mapped, including at the single-nucleotide polymorphism rs6516886. Previous analysis of OA cartilage DNA identified 6 CpG dinucleotides whose methylation levels correlated with the rs6516886 genotype, forming methylation quantitative trait loci (mQTLs). We undertook this study to investigate these mQTLs and to map expression...
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