Article
A blood pressure genetic risk score is a significant predictor of incident cardiovascular events in 32,669 individuals.
Hypertension (Dallas, Tex. : 1979) - 1 May 2013
Havulinna Aki S, Kettunen Johannes, Ukkola Olavi, Osmond Clive, Eriksson Johan G, Kesäniemi Y Antero, Jula Antti, Peltonen Leena, Kontula Kimmo, Salomaa Veikko, Newton-Cheh Christopher
Abstract excerpt
Recent genome-wide association studies have identified genetic variants associated with blood pressure (BP). We investigated whether genetic risk scores (GRSs) constructed of these variants would predict incident cardiovascular disease (CVD) events. We genotyped 32 common single nucleotide polymorphisms in several Finnish cohorts, with up to 32,669 individuals after exclusion of prevalent CVD cases. The median...
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