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Article

Whole-Genome Approach Discovers Novel Genetic and Nongenetic Variance Components Modulated by Lifestyle for Cardiovascular Health.

Journal of the American Heart Association - 21 Apr 2020

Zhou Xuan, van der Werf Julius, Carson-Chahhoud Kristin, Ni Guiyan, McGrath John, Hyppönen Elina, Lee S Hong

Abstract excerpt

Background Both genetic and nongenetic factors can predispose individuals to cardiovascular risk. Finding ways to alter these predispositions is important for cardiovascular disease prevention. Methods and Results We used a novel whole-genome approach to estimate the genetic and nongenetic effects on-and hence their predispositions to-cardiovascular risk and determined whether they vary with respect to lifestyle...

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Cardiovascular Diseases
Gene-Environment Interaction
Healthy Lifestyle
Heart Disease Risk Factors
Heredity

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Risk Reduction Behavior

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PMID: 32308100
DOI: 10.1161/JAHA.119.015661
PMCID: PMC7428517

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