Article
Polygenic Interactions With Environmental Exposures in Blood Pressure Regulation: The HUNT Study.
Journal of the American Heart Association - 1 Oct 2024
Øvretveit Karsten, Ingeström Emma M L, Spitieris Michail, Tragante Vinicius, Thomas Laurent F, Steinsland Ingelin, Brumpton Ben M, Gudbjartsson Daniel F, Holm Hilma, Stefansson Kari, Wisløff Ulrik, Hveem Kristian
Abstract excerpt
BACKGROUND: The essential hypertension phenotype results from an interplay between genetic and environmental factors. The influence of lifestyle exposures such as excess adiposity, alcohol consumption, tobacco use, diet, and activity patterns on blood pressure (BP) is well established. Additionally, polygenic risk scores for BP traits are associated with clinically significant phenotypic variation. However,...
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