Article
Association of oligodendrocytes differentiation regulator gene DUSP15 with autism.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Mar 2017
Tian Ye, Wang Lifang, Jia Meixiang, Lu Tianlan, Ruan Yanyan, Wu Zhiliu, Wang Linyan, Liu Jing, Zhang Dai
Abstract excerpt
OBJECTIVES: Autism is a pervasive neurodevelopmental disorder with high heritability. Genetic factors play crucial roles in the aetiology of autism. Dual specificity phosphatase 15 (DUSP15) has been recognised as a key regulator gene for oligodendrocytes differentiation. A previous study detected one de novo missense variant (p.Thr107Met) with probable deleterious function in exon 6 of DUSP15 among patients with...
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