Article
Rare FBXO18 variations and risk of schizophrenia: Whole-exome sequencing in two parent-affected offspring trios followed by resequencing and case-control studies.
Psychiatry and clinical neurosciences - 1 Aug 2017
Hoya Satoshi, Watanabe Yuichiro, Hishimoto Akitoyo, Nunokawa Ayako, Inoue Emiko, Igeta Hirofumi, Otsuka Ikuo, Shibuya Masako, Egawa Jun, Sora Ichiro, Someya Toshiyuki
Abstract excerpt
AIM: Rare variations are suggested to play a role in the genetic etiology of schizophrenia; to further investigate their role, we performed a three-stage study in a Japanese population. METHODS: In the first stage, we performed whole-exome sequencing (WES) of two parent-affected offspring trios. In the second stage, we resequenced the FBXO18 coding region in 96 patients. In the third stage, we tested rare...
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