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Article

FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease.

PloS one - 1 Jan 2014

Chen Chiung-Mei, Chen I-Cheng, Huang Yi-Cheng, Juan Hsueh-Fen, Chen Ying-Lin, Chen Yi-Chun, Lin Chih-Hsin, Lee Li-Ching, Lee Chi-Mei, Lee-Chen Guey-Jen, Lai Yun-Ju, Wu Yih-Ru

Abstract excerpt

Mutations in the F-box only protein 7 gene (FBXO7), the substrate-specifying subunit of SCF E3 ubiquitin ligase complex, cause Parkinson's disease (PD)-15 (PARK15). To identify new variants, we sequenced FBXO7 cDNA in 80 Taiwanese early onset PD patients (age at onset ≤ 50) and only two known variants, Y52C (c.155A>G) and M115I (c.345G>A), were found. To assess the association of Y52C and M115I with the risk of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25029497
DOI: 10.1371/journal.pone.0101392
PMCID: PMC4100735

Genes

FBXO7
TRAF2
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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