Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.

Molecular and cellular biology - 1 Jul 2009

Saiga Toru, Fukuda Takaichi, Matsumoto Masaki, Tada Hirobumi, Okano Hirotaka James, Okano Hideyuki, Nakayama Keiichi I

Abstract excerpt

Fbxo45 is an F-box protein that is restricted to the nervous system. Unlike other F-box proteins, Fbxo45 was found not to form an SCF complex as a result of an amino acid substitution in the consensus sequence for Cul1 binding. Proteomics analysis revealed that Fbxo45 specifically associates with PAM (protein associated with Myc), a RING finger-type ubiquitin ligase. Mice deficient in Fbxo45 were generated and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to F-Box Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Multiprotein Complexes

Share to Neural Pathways

Share to Neurogenesis

Share to Neuromuscular Junction

Share to Spinal Cord

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 19398581
DOI: 10.1128/MCB.00364-09
PMCID: PMC2698766

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.PMID 19398581Read ↗

The UFM1 conjugation system in mammalian developmentSemantic proximity Read ↗

Deficiency of murine UFM1-specific E3 ligase causes microcephaly and inflammationSemantic proximity Read ↗

The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in miceSemantic proximity Read ↗

Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5.Semantic proximity Read ↗

Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradationSemantic proximity Read ↗

Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor functionSemantic proximity Read ↗

The deubiquitinase Leon/USP5 regulates ubiquitin homeostasis during Drosophila development.Semantic proximity Read ↗

The F-box protein MEC-15 (FBXW9) promotes synaptic transmission in GABAergic motor neurons in C. elegans.Semantic proximity Read ↗

Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy.Semantic proximity Read ↗

Gene expression in the developing diaphragm: significance for congenital diaphragmatic herniaSemantic proximity Read ↗

mec-15 encodes an F-box protein required for touch receptor neuron mechanosensation, synapse formation and development.Semantic proximity Read ↗

Nox5 and the Regulation of Cellular FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.