Blood cis-eQTL analysis fails to identify novel association signals among sub-threshold candidates from genome-wide association studies in restless legs syndrome.

doi:10.1371/journal.pone.0098092

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Article

Blood cis-eQTL analysis fails to identify novel association signals among sub-threshold candidates from genome-wide association studies in restless legs syndrome.

PloS one - 1 Jan 2014

Schulte Eva C, Schramm Katharina, Schurmann Claudia, Lichtner Peter, Herder Christian, Roden Michael, Gieger Christian, Peters Annette, Trenkwalder Claudia, Högl Birgit, Frauscher Birgit, Berger Klaus, Fietze Ingo, Gross Nadine, Stiasny-Kolster Karin, Oertel Wolfgang, Bachmann Cornelius G, Paulus Walter, Zimprich Alexander, Völzke Henry, Schminke Ulf, Nauck Matthias, Illig Thomas, Meitinger Thomas, Müller-Myhsok Bertram, Prokisch Holger, Winkelmann Juliane

Abstract excerpt

Restless legs syndrome (RLS) is a common neurologic disorder characterized by nightly dysesthesias affecting the legs primarily during periods of rest and relieved by movement. RLS is a complex genetic disease and susceptibility factors in six genomic regions have been identified by means of genome-wide association studies (GWAS). For some complex genetic traits, expression quantitative trait loci (eQTLs) are...

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PMID: 24875634
DOI: 10.1371/journal.pone.0098092
PMCID: PMC4038519

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