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Article

ExomeChip-based rare variant association study in restless legs syndrome.

Sleep medicine - 1 Jun 2022

Tilch Erik, Schormair Barbara, Zhao Chen, Högl Birgit, Stefani Ambra, Berger Klaus, Trenkwalder Claudia, Bachmann Cornelius G, Hornyak Magdolna, Fietze Ingo, Müller-Nurasyid Martina, Peters Annette, Herms Stefan, Nöthen Markus M, Müller-Myhsok Bertram, Oexle Konrad, Winkelmann Juliane

Abstract excerpt

Restless legs syndrome (RLS) is a common sleep-related movement disorder in populations of European descent and disease risk is strongly influenced by genetic factors. Common variants have been assessed extensively in several genome-wide association studies, but the contribution of rarer genetic variation has not been investigated at this scale. We therefore genotyped a case-control set of 9246 individuals for...

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PMID: 35489115
DOI: 10.1016/j.sleep.2022.04.001

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