Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Poly (ADP-ribose) in the pathogenesis of Parkinson's disease

31 Aug 2014

Abstract excerpt

The defining feature of Parkinson's disease is a progressive and selective demise of dopaminergic neurons. A recent report on Parkinson's disease animal model demonstrates that poly (ADP-ribose) (PAR) dependent cell death, also named parthanatos, is accountable for selective dopaminergic neuronal loss. Parthanatos is a programmed necrotic cell death, characterized by PARP1 activation, apoptosis inducing factor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium signaling and nucleotide metabolism
Share to Parkinson's Disease Mechanisms and Treatments
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24874851
DOI: 10.5483/bmbrep.2014.47.8.119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Poly (ADP-ribose) in the pathogenesis of Parkinson's diseasePMID 24874851Read ↗

Poly (ADP-Ribose) polymerase 1 and parthanatos in neurological diseases: From pathogenesis to therapeutic opportunitiesSemantic proximity Read ↗

Parthanatos: mitochondrial‐linked mechanisms and therapeutic opportunitiesSemantic proximity Read ↗

Parthanatos, a messenger of deathSemantic proximity Read ↗

Pharmacologic inhibition of MIF nuclease: A new treatment paradigm to treat cell deathSemantic proximity Read ↗

Mitochondrial and Nuclear Cross Talk in Cell DeathSemantic proximity Read ↗

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Exploring the role of parthanatos in CNS injury: Molecular insights and therapeutic approachesSemantic proximity Read ↗

Poly ADP-Ribose Signaling is Dysregulated in Huntington DiseaseSemantic proximity Read ↗

Emerging role of PARP‐1 and PARthanatos in ischemic strokeSemantic proximity Read ↗

Poly(ADP‐ribose)Semantic proximity Read ↗

PARG activity is required for cell death by parthanatosSemantic proximity Read ↗

Poly ADP-ribose signaling is dysregulated in Huntington diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.