Parthanatos: mitochondrial‐linked mechanisms and therapeutic opportunities

Abstract excerpt

Cells die by a variety of mechanisms. Terminally differentiated cells such as neurones die in a variety of disorders, in part, via parthanatos, a process dependent on the activity of poly ( ADP ‐ribose)‐polymerase ( PARP ). Parthanatos does not require the mediation of caspases for its execution, but is clearly mechanistically dependent on the nuclear translocation of the mitochondrial‐associated...

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