PARG activity is required for cell death by parthanatos

Abstract excerpt

Cell death by a non-apoptotic pathway termed parthanatos is induced by hyperactivation of the DNA damage sensor PARP1, which uses NAD + as a substrate to catalyse the poly-ADP-ribosylation (PARylation) of proteins. Parthanatos has been implicated in several pathological conditions such as ischaemia-reperfusion injury and neurodegenerative processes, including Alzheimeŕs and Parkinsońs diseases, as well as rare ge...

Topics

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• Cell death mechanisms and regulation
• Enzyme Inhibitors
• Gene Knockdown Techniques
• Glycoside Hydrolases
• HeLa Cells
• PARP inhibition in cancer therapy
• Poly(ADP-ribose) Polymerase Inhibitors
• Poly(ADP-ribose) Polymerases

Identifiers and source

Literature Corpus work

1e5422ae-b6b2-5595-8d55-de74a5171b35

DOI

10.64898/2026.05.12.724507