Article
Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis.
Acta neuropathologica communications - 29 Aug 2018
McGurk L, Mojsilovic-Petrovic J, Van Deerlin V M, Shorter J, Kalb R G, Lee V M, Trojanowski J Q, Lee E B, Bonini N M
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease. Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly leading to death within ~ 2-5 years of symptomatic onset. There is no cure, and the few available treatments offer only a modest extension in patient survival. A protein central to ALS is the nuclear RNA/DNA-binding protein, TDP-43. In > 95%...
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