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Exploring the role of parthanatos in CNS injury: Molecular insights and therapeutic approaches

3 May 2024

Abstract excerpt

BACKGROUND: Central nervous system (CNS) injury causes severe organ damage due to both damage resulting from the injury and subsequent cell death. However, there are currently no effective treatments for countering the irreversible loss of cell function. Parthanatos is a poly (ADP-ribose) polymerase 1 (PARP-1)-dependent form of programmed cell death that is partly responsible for neural cell death. Consequently,...

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PMID: 38704090
DOI: 10.1016/j.jare.2024.04.031

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