Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features.

doi:10.1007/s00535-015-1126-4

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Article

Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features.

Journal of gastroenterology - 1 May 2016

Kawai-Kitahata Fukiko, Asahina Yasuhiro, Tanaka Shinji, Kakinuma Sei, Murakawa Miyako, Nitta Sayuri, Watanabe Takako, Otani Satoshi, Taniguchi Miki, Goto Fumio, Nagata Hiroko, Kaneko Shun, Tasaka-Fujita Megumi, Nishimura-Sakurai Yuki, Azuma Seishin, Itsui Yasuhiro, Nakagawa Mina, Tanabe Minoru, Takano Shinichi, Fukasawa Mitsuharu, Sakamoto Minoru, Maekawa Shinya, Enomoto Nobuyuki, Watanabe Mamoru

Abstract excerpt

BACKGROUND AND AIMS: Genetic alterations in specific genes are critical events in carcinogenesis and hepatocellular carcinoma (HCC) progression. However, the genetic alterations responsible for HCC development, progression, and survival are unclear. METHODS: We investigated the essential difference in genetic alterations between HCC and adjacent non-HCC tissues using next-generation sequencing technology....

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PMID: 26553052
DOI: 10.1007/s00535-015-1126-4

Genes

TERT
CTNNB1
AXIN1
PTEN

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