Article
SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.
Haematologica - 1 Aug 2014
Simonetti Giorgia, Bertilaccio Maria Teresa Sabrina, Rodriguez Tania Veliz, Apollonio Benedetta, Dagklis Antonis, Rocchi Martina, Innocenzi Anna, Casola Stefano, Winkler Thomas H, Nitschke Lars, Ponzoni Maurilio, Caligaris-Cappio Federico, Ghia Paolo
Abstract excerpt
The sialic-acid-binding immunoglobulin-like lectin SIGLEC-G is a negative regulator of B-cell receptor-mediated calcium signaling. Its deficiency leads to reduced turnover and increased proliferation and survival of murine B-1a cells. Siglecg(-/-) mice show a premature expansion of polyclonal CD5(+) B cells in the spleen and the peritoneal cavity. Here we studied the fate of B lymphocytes in Siglecg(-/-) mice...
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