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Article

Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice.

DNA repair - 8 Dec 2005

Andersen Sonja, Ericsson Madelene, Dai Hong Yan, Peña-Diaz Javier, Slupphaug Geir, Nilsen Hilde, Aarset Harald, Krokan Hans E

Abstract excerpt

Ung-deficient mice have reduced class switch recombination, skewed somatic hypermutation, lymphatic hyperplasia and a 22-fold increased risk of developing B-cell lymphomas. We find that lymphomas are of follicular (FL) and diffuse large B-cell type (DLBCL). All FLs and 75% of the DLBCLs were monoclonal while 25% were biclonal. Monoclonality was also observed in hyperplasia, and could represent an early stage of...

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Identifiers

PMID: 16174566
DOI: 10.1016/j.dnarep.2005.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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