Article
Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain.
Cell death and differentiation - 1 Mar 2010
Qiao G, Li Z, Minto A W, Shia J, Yang L, Bao L, Tschopp J, Gao J-X, Wang J, Quigg R J, Zhang J
Abstract excerpt
The cellular FLICE inhibitory protein (c-FLIP) is an endogenous inhibitor of the caspase-8 proapoptotic signaling pathway downstream of death receptors. Recent evidence indicates that the long form of c-FLIP (c-FLIP(L)) is required for proliferation and effector T-cell development. However, the role of c-FLIP(L) in triggering autoimmunity has not been carefully analyzed. We now report that c-FLIP(L) transgenic...
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