Article
Integrative analyses uncover mechanisms by which aging drives B cell lymphoma
2021-02-23
Abstract excerpt
While cancer is an age-related disease, many cancer studies utilize younger animal models. Here, we uncover how a cancer, B-cell lymphoma, develops as a consequence of a naturally aged system. We show that this malignancy is associated with increased cell size, splenomegaly, and a newly discovered age-associated clonal B-cell (ACBC) population. Driven by exogenous c-Myc activation, hypermethylated promoters and so...
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Identifiers and source
- Literature Corpus work
- 752d7c30-8c66-5cda-9f37-ac3231eb7ca0
- DOI
- 10.1101/2021.02.23.432500