Article
Bad-deficient mice develop diffuse large B cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003
Ranger Ann M, Zha Jiping, Harada Hisashi, Datta Sandeep Robert, Danial Nika N, Gilmore Andrew P, Kutok Jeffery L, Le Beau Michelle M, Greenberg Michael E, Korsmeyer Stanley J
Abstract excerpt
The proapoptotic activity of the "BH3-only" molecule BAD can be differentially regulated by survival factor signaling. Bad-deficient mice lacking both BAD long and BAD short proteins proved viable, and most cell types appeared to develop normally. BAD did not exclusively account for cell death after withdrawal of survival factors, but it was an intermediate for epidermal growth factor- or insulin-like growth...
Topics
- Animals
- Apoptosis
- B-Lymphocytes
- Carrier Proteins
- Cell Death
- Cell Lineage
- DNA, Complementary
- Exons
- Gamma Rays
- Immunoglobulin G
- Karyotyping
- Lymphoma, B-Cell
- Mice
- Mice, Inbred C57BL