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Article

Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation.

Cancer research - 15 Nov 2009

Cattoretti Giorgio, Mandelbaum Jonathan, Lee Nancy, Chaves Alicia H, Mahler Ashley M, Chadburn Amy, Dalla-Favera Riccardo, Pasqualucci Laura, MacLennan A John

Abstract excerpt

S1P(2) sphingosine 1-phosphate receptor signaling can regulate proliferation, survival, morphology, and migration in many cell types in vitro. Here, we report that S1P(2)(-/-) mice develop clonal B-cell lymphomas with age, such that approximately half of the animals display this neoplasm by 1.5 t...

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Source

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Identifiers

PMID: 19903857
DOI: 10.1158/0008-5472.CAN-09-1110
PMCID: PMC2973841

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19903857-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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