Article

The Role of Glycosphingolipids in Autoimmune Manifestations and Myeloma in Gaucher Disease

2025-07-31

Abstract excerpt

Gaucher disease, an inborn error of glucosylceramide recycling, predisposes to haematological malignancies, liver cirrhosis and cancer. Inducible Gaucher disease modelled in susceptible mouse strains showed striking autoimmune hepatitis and cancer development; as reported previously, they also develop monoclonal immunoglobulins and B-cell tumours. Exposure to eliglustat, a therapeutic inhibitor of glucosylceramide...

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Literature Corpus work: fa67e091-69e8-5459-969f-60bb4b265f3f
DOI: 10.1101/2025.07.28.666118

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