Article
Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2001
Zhu G, Flies D B, Tamada K, Sun Y, Rodriguez M, Fu Y X, Chen L
Abstract excerpt
Interaction of 4-1BB (CD137) and its ligand (4-1BBL) is thought to positively regulate cell-mediated and humoral immune responses. We have prepared transgenic mouse strains that express 4-1BBL cDNA under the control of MHC class II I-Ealpha promoter. The 4-1BBL-transgenic mice show progressive splenomegaly and selective depletion of B220(+) B cells accompanied with low levels of circulating IgG and defective...
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