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Article

Short-term memory advantage for brief durations in human APOE ε4 carriers.

Scientific reports - 11 Jun 2020

Zokaei Nahid, Grogan John, Fallon Sean James, Slavkova Ellie, Hadida Jonathan, Manohar Sanjay, Nobre Anna Christina, Husain Masud

Abstract excerpt

The Apolipoprotein-E (APOE) ε4 gene allele, the highest known genetic risk factor for Alzheimer's disease, has paradoxically been well preserved in the human population. One possible explanation offered by evolutionary biology for survival of deleterious genes is antagonistic pleiotropy. This theory proposes that such genetic variants might confer an advantage, even earlier in life when humans are also...

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Identifiers

PMID: 32528115
DOI: 10.1038/s41598-020-66114-6
PMCID: PMC7289888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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