Article
The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study.
Neuropsychology - 1 Jan 2013
Brainerd C J, Reyna V F, Petersen R C, Smith G E, Kenney A E, Gross C J, Taub E S, Plassman B L, Fisher G G
Abstract excerpt
OBJECTIVE: The ε4 allele of the apolipoprotein E (APOE) genotype is the most widely accepted genetic risk factor for Alzheimer's dementia (AD), but findings on whether it is a risk factor for the AD prodrome, mild cognitive impairment (MCI), have been inconsistent. In a prospective longitudinal d...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoproteins E
- Cognitive Dysfunction
- Disease Progression
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Genotype
- Humans
- Logistic Models
- Longitudinal Studies
- Male