Article
The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study.
Neuropsychology - 1 Jan 2013
Brainerd C J, Reyna V F, Petersen R C, Smith G E, Kenney A E, Gross C J, Taub E S, Plassman B L, Fisher G G
Abstract excerpt
OBJECTIVE: The ε4 allele of the apolipoprotein E (APOE) genotype is the most widely accepted genetic risk factor for Alzheimer's dementia (AD), but findings on whether it is a risk factor for the AD prodrome, mild cognitive impairment (MCI), have been inconsistent. In a prospective longitudinal design, we investigated (a) whether transitions to MCI and other forms of neurocognitive impairment without dementia...
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