Article

APOBEC3C tandem domain proteins create super restriction factors against HIV-1

2020-03-29

Abstract excerpt

Humans encode proteins, called restriction factors, that inhibit replication of viruses like HIV-1. One family of antiviral proteins, apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 ( APOBEC3, shortened to A3) acts by deaminating cytidines to uridines during the reverse transcription reaction of HIV-1. The A3 locus encodes seven genes, named A3A - A3H . These genes either have one or two cyti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eb664841-572d-59fd-8339-5afd78981fed
DOI: 10.1101/2020.03.27.012963

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

APOBEC3C tandem domain proteins create super restriction factors against HIV-1DOI 10.1101/2020.03.27.012963Read

Role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancerSemantic proximity Read

Antiviral Mechanism and Biochemical Basis of the Human APOBEC3 FamilySemantic proximity Read

Vpr.A3A Chimera Inhibits HIV ReplicationSemantic proximity Read

APOBEC3 family proteins as drivers of virus evolutionSemantic proximity Read

The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous RetroelementsSemantic proximity Read

Cytidine Deaminases as a Weapon Against Retroviruses and a New Target for Antiviral TherapySemantic proximity Read

Mechanism of Enhanced HIV Restriction by Virion Coencapsidated Cytidine Deaminases APOBEC3F and APOBEC3GSemantic proximity Read

Loop 1 of APOBEC3C regulates its antiviral activity against HIV-1Semantic proximity Read

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeuticsSemantic proximity Read

Retroelements versus APOBEC3 family members: No great escape from the magnificent sevenSemantic proximity Read

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.Semantic proximity Read

Different Modes of Retrovirus Restriction by Human APOBEC3A and APOBEC3G In VivoSemantic proximity Read