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Mouse APOBEC3 Restricts Friend Leukemia Virus Infection and Pathogenesis In Vivo

12 Sept 2008

Abstract excerpt

Several members of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like complex 3 (APOBEC3) family in primates act as potent inhibitors of retroviral replication. However, lentiviruses have evolved mechanisms to specifically evade host APOBEC3. Likewise, murine leukemia viruses (MuLV) exclude mouse APOBEC3 from the virions and cleave virion-incorporated APOBEC3. Although the betaretrovirus mouse...

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Identifiers

PMID: 18786991
DOI: 10.1128/jvi.01311-08

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