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Article

Linkage disequilibrium and signatures of positive selection around LINE-1 retrotransposons in the human genome.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jun 2014

Kuhn Alexandre, Ong Yao Min, Cheng Ching-Yu, Wong Tien Yin, Quake Stephen R, Burkholder William F

Abstract excerpt

Insertions of the human-specific subfamily of LINE-1 (L1) retrotransposon are highly polymorphic across individuals and can critically influence the human transcriptome. We hypothesized that L1 insertions could represent genetic variants determining important human phenotypic traits, and performed an integrated analysis of L1 elements and single nucleotide polymorphisms (SNPs) in several human populations. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24847061
DOI: 10.1073/pnas.1401532111
PMCID: PMC4050588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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