Variation in AKR1C3, which encodes the neuroactive steroid synthetic enzyme 3α-HSD type 2 (17β-HSD type 5), moderates the subjective effects of alcohol.

doi:10.1007/s00213-014-3614-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Variation in AKR1C3, which encodes the neuroactive steroid synthetic enzyme 3α-HSD type 2 (17β-HSD type 5), moderates the subjective effects of alcohol.

Psychopharmacology - 1 Sept 2014

Milivojevic Verica, Feinn Richard, Kranzler Henry R, Covault Jonathan

Abstract excerpt

RATIONALE: Animal models suggest that neuroactive steroids contribute to alcohol's acute effects. We previously reported that a common nonsynonymous polymorphism, AKR1C3 2 in the gene encoding the enzyme 3α-HSD2/17β-HSD5, and a synonymous single nucleotide polymorphism (SNP), rs248793, in SRD5A1, which encodes 5α-reductase, were associated with alcohol dependence (AD). OBJECTIVES: The aim of the study was to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3-Hydroxysteroid Dehydrogenases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Alcohol Drinking

Share to Alcoholism

Share to Central Nervous System Depressants

Share to Double-Blind Method

Share to Ethanol

Share to Receptors, GABA-A

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 24838369
DOI: 10.1007/s00213-014-3614-2
PMCID: PMC4135039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation in AKR1C3, which encodes the neuroactive steroid synthetic enzyme 3α-HSD type 2 (17β-HSD type 5), moderates the subjective effects of alcohol.PMID 24838369Read ↗

Variation in genes encoding the neuroactive steroid synthetic enzymes 5α-reductase type 1 and 3α-reductase type 2 is associated with alcohol dependence.Semantic proximity Read ↗

Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical ReviewSemantic proximity Read ↗

Associations of variations in alcohol dehydrogenase genes with the level of response to alcohol in non-Asians.Semantic proximity Read ↗

Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.Semantic proximity Read ↗

Candidate genes for alcohol dependence: A genetic association study from India.Semantic proximity Read ↗

GABRA2 markers moderate the subjective effects of alcohol.Semantic proximity Read ↗

A novel polymorphism in the 17beta-hydroxysteroid dehydrogenase type 5 (aldo-keto reductase 1C3) gene is associated with lower serum testosterone levels in caucasian men.Semantic proximity Read ↗

GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride.Semantic proximity Read ↗

Multiple polymorphisms in genes of the adrenergic stress system confer vulnerability to alcohol abuse.Semantic proximity Read ↗

Associations of ALDH2 and ADH1B genotypes with response to alcohol in Asian Americans.Semantic proximity Read ↗

Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences.Semantic proximity Read ↗

The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.