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Article

Variation in genes encoding the neuroactive steroid synthetic enzymes 5α-reductase type 1 and 3α-reductase type 2 is associated with alcohol dependence.

Alcoholism, clinical and experimental research - 1 May 2011

Milivojevic Verica, Kranzler Henry R, Gelernter Joel, Burian Linda, Covault Jonathan

Abstract excerpt

BACKGROUND: Studies of alcohol effects in rodents and in vitro implicate endogenous neuroactive steroids as key mediators of alcohol effects at GABA(A) receptors. We used a case-control sample to test the association with alcohol dependence (AD) of single nucleotide polymorphisms in the genes encoding two key enzymes required for the generation of endogenous neuroactive steroids: 5α-reductase, type I (5α-R), and...

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Identifiers

PMID: 21323680
DOI: 10.1111/j.1530-0277.2010.01425.x
PMCID: PMC3083475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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