Article
Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60.
Cell reports - 12 Jun 2014
Xiao Yan, Nagai Yasuhiro, Deng Guoping, Ohtani Takuya, Zhu Zhiqiang, Zhou Zhaocai, Zhang Hongtao, Ji Mei Q, Lough John W, Samanta Arabinda, Hancock Wayne W, Greene Mark I
Abstract excerpt
The human FOXP3 molecule is an oligomeric transcriptional factor able to mediate activities that characterize T regulatory cells, a class of lymphocytes central to the regulation of immune responses. The activity of FOXP3 is regulated at the posttranslational level, in part by two histone acetyltransferases (HATs): TIP60 and p300. TIP60 and p300 work cooperatively to regulate FOXP3 activity. Initially, p300 and...
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