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Article

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

8 Dec 2009

Abstract excerpt

Regulatory T cells (Tregs) are a specific subset of lymphocytes that are critical for the maintenance of self-tolerance. Expression levels of the transcription factor Foxp3 have been causally associated with Treg differentiation and function. Recent studies show that Foxp3 can also be transiently expressed in effector T cells; however, stable Foxp3 expression is required for development of a functional Treg...

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PMID: 19996091
DOI: 10.1182/blood-2009-02-207118

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