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Article

Lysosome-dependent p300/FOXP3 degradation and limits Treg cell functions and enhances targeted therapy against cancers.

Experimental and molecular pathology - 1 Aug 2013

Du Taofeng, Nagai Yasuhiro, Xiao Yan, Greene Mark I, Zhang Hongtao

Abstract excerpt

p300 is one of several acetyltransferases that regulate FOXP3 acetylation and functions. Our recent studies have defined a complex set of histone acetyltransferase interactions which can lead to enhanced or repressed changes in FOXP3 function. We have explored the use of a natural p300 inhibitor, Garcinol, as a tool to understand mechanisms by which p300 regulates FOXP3 acetylation. In the presence of Garcinol,...

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Topics

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to E1A-Associated p300 Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 23644046
DOI: 10.1016/j.yexmp.2013.04.003
PMCID: PMC3963828

Genes

FOXP3
ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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