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Article

Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2007

Liu Yang, Li Liunan, Kumar Kirthi Raman, Xie Chun, Lightfoot Skip, Zhou Xin J, Kearney John F, Weigert Martin, Mohan Chandra

Abstract excerpt

An NZM2410-derived lupus susceptibility locus on murine chromosome 4, Sle2(z), has previously been noted to engender generalized B cell hyperactivity. To study how Sle2(z) impacts B cell tolerance, two Ig H chain site-directed transgenes, 3H9 and 56R, with specificity for DNA were backcrossed onto the C57BL/6 background with or without Sle2(z). Interestingly, the presence of the NZM2410 "z" allele of Sle2 on the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Genes, Immunoglobulin Heavy Chain

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Source

Identifiers

PMID: 17617627
DOI: 10.4049/jimmunol.179.2.1340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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