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Article

Regulation of B cell tolerance by the lupus susceptibility gene Ly108.

Science (New York, N.Y.) - 16 Jun 2006

Kumar Kirthi Raman, Li Liunan, Yan Mei, Bhaskarabhatla Madhavi, Mobley Angela B, Nguyen Charles, Mooney Jill M, Schatzle John D, Wakeland Edward K, Mohan Chandra

Abstract excerpt

The susceptibility locus for the autoimmune disease lupus on murine chromosome 1, Sle1z/Sle1bz, and the orthologous human locus are associated with production of autoantibody to chromatin. We report that the presence of Sle1z/Sle1bz impairs B cell anergy, receptor revision, and deletion. Members of the SLAM costimulatory molecule family constitute prime candidates for Sle1bz, among which the Ly108.1 isoform of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16778059
DOI: 10.1126/science.1125893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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