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Article

Genetic dissection of lupus pathogenesis: Sle3/5 impacts IgH CDR3 sequences, somatic mutations, and receptor editing.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2004

Wakui Masatoshi, Kim Jinho, Butfiloski Edward J, Morel Laurence, Sobel Eric S

Abstract excerpt

Sle3/5 is a lupus susceptibility locus identified on mouse chromosome 7 of the New Zealand Black/New Zealand White (NZB/NZW)-derived NZM2410 strain. Based on previous observations, this locus appears to contribute to lupus pathogenesis through its impact on diversification of immune responses. To understand how Sle3/5 affects somatic diversification of humoral responses, we analyzed IgH rearrangements...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Circular

Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Share to Genes, RAG-1

Share to Immunoglobulin Heavy Chains

Share to Receptors, Antigen, B-Cell

Share to Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 15585861
DOI: 10.4049/jimmunol.173.12.7368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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