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Article

Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.

Nature communications - 16 Aug 2021

Agnew Christopher, Ayaz Pelin, Kashima Risa, Loving Hanna S, Ghatpande Prajakta, Kung Jennifer E, Underbakke Eric S, Shan Yibing, Shaw David E, Hata Akiko, Jura Natalia

Abstract excerpt

Upon ligand binding, bone morphogenetic protein (BMP) receptors form active tetrameric complexes, comprised of two type I and two type II receptors, which then transmit signals to SMAD proteins. The link between receptor tetramerization and the mechanism of kinase activation, however, has not been elucidated. Here, using hydrogen deuterium exchange mass spectrometry (HDX-MS), small angle X-ray scattering (SAXS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34400635
DOI: 10.1038/s41467-021-25248-5
PMCID: PMC8368100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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