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Article

Ab initio modeling and experimental assessment of Janus Kinase 2 (JAK2) kinase-pseudokinase complex structure.

PLoS computational biology - 1 Apr 2013

Wan Xiaobo, Ma Yue, McClendon Christopher L, Huang Lily Jun-shen, Huang Niu

Abstract excerpt

The Janus Kinase 2 (JAK2) plays essential roles in transmitting signals from multiple cytokine receptors, and constitutive activation of JAK2 results in hematopoietic disorders and oncogenesis. JAK2 kinase activity is negatively regulated by its pseudokinase domain (JH2), where the gain-of-function mutation V617F that causes myeloproliferative neoplasms resides. In the absence of a crystal structure of...

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Identifiers

PMID: 23592968
DOI: 10.1371/journal.pcbi.1003022
PMCID: PMC3616975

Genes

JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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